LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion
نویسندگان
چکیده
منابع مشابه
Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion.
The centrosome duplicates during the cell cycle but functions as a single microtubule-organising centre until shortly before mitosis. This raises the question of how centrosome cohesion is maintained throughout interphase. One dynamic model proposes that parental centrioles are held together through centriole-associated, entangling filaments. Central to this model are C-Nap1, a putative centrio...
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Duplicating centrosomes are paired during interphase, but are separated at the onset of mitosis. Although the mechanisms controlling centrosome cohesion and separation are important for centrosome function throughout the cell cycle, they remain poorly understood. Recently, we have proposed that C-Nap1, a novel centrosomal protein, is part of a structure linking parental centrioles in a cell cyc...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2013
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2013.08.005